DRPSHP

Scientific Reference

CJC-1295 (without DAC)

Evidence profile: Controlled human evidence

This page describes the shorter-acting CJC-1295, known in the literature as modified GRF(1-29), which has no drug affinity complex attached. It keeps the first 29 residues of growth hormone-releasing hormone, the stretch that does the receptor binding, out of the 44 in the full hormone, and four substitutions are made to that stretch to protect it from breakdown. Be careful with the name, since CJC-1295 was first used for a version bearing the drug affinity complex (DAC), a reactive linker that binds albumin and prolongs circulation; that version is covered on its own page. Human studies of the DAC form are few, and for the form without DAC the published record is smaller again, so a lot of what is said rests on what is known about the parent hormone.

Mechanism of Action

Like the natural hormone, it is reported to bind the GHRH receptor, a class B G protein-coupled receptor on somatotrophs of the anterior pituitary, coupling through Gs to raise cAMP and release stored growth hormone; the growth hormone then stimulates IGF-1 production, mostly in the liver. The four changes are D-alanine at position 2, glutamine at 8, alanine at 15 and leucine at 27. They are meant to block dipeptidyl peptidase-4 cleavage and limit deamidation and oxidation at sensitive residues. With no albumin-binding linker the circulating half-life is short, and pharmacokinetic data for this specific form are sparse.

Molecular Information

  • Type: GHRH analogue (modified GRF 1-29)
  • Molecular weight: 3647.2 g/mol
  • Molecular formula: C165H269N47O46

Published Research

  • Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults

    Teichman SL et al. · The Journal of clinical endocrinology and metabolism · 2006 · Clinical

    PMID 16352683 — View on PubMed

  • Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog

    Ionescu M et al. · The Journal of clinical endocrinology and metabolism · 2006 · Clinical

    PMID 17018654 — View on PubMed