DRPSHP

Scientific Reference

BPC-157

Evidence profile: Preclinical, with limited uncontrolled human reports

BPC-157 is a synthetic chain of fifteen amino acids taken from a longer protein that was reported in human gastric juice and called body protection compound. That parent protein is described chiefly by the group who proposed it, and the peptide itself is known almost solely through the same group's output. The experiments are overwhelmingly in rodents and cover injury models of tendon, ligament, muscle and bone, damage to the stomach and intestine, and a number of nervous-system models. Human evidence amounts to a few small reports, not controlled trials, and replication by laboratories independent of the originators is limited.

Mechanism of Action

BPC-157 has no identified receptor. Rodent and cell experiments have recorded effects on several signalling systems: most frequently the nitric oxide system, VEGF receptor 2 signalling in endothelial cells, and the FAK-paxillin pathway in cultured tendon fibroblasts. Some animal papers describe links to dopamine and serotonin systems, and others have measured growth-factor and early-response gene expression in damaged tissue. Since these results come from few laboratories using different models, the mechanism is better described as unresolved than as a known pathway.

Molecular Information

  • Type: Pentadecapeptide
  • Molecular weight: 1419.5 g/mol
  • Molecular formula: C62H98N16O22
  • CAS: 137525-51-0

Published Research

  • Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians

    Mayfield CK et al. · The American journal of sports medicine · 2026 · Review

    PMID 41476424 — View on PubMed

  • From Regeneration to Analgesia: The Role of BPC-157 in Tissue Repair and Pain Management

    Yuan C et al. · International journal of molecular sciences · 2026 · Review

    PMID 41898733 — View on PubMed

  • Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study

    Lee E et al. · Alternative therapies in health and medicine · 2024 · Clinical

    PMID 39325560 — View on PubMed

  • Protective effects of BPC 157 in rats with experimentally induced lower extremity ischemia-reperfusion injury

    Yıldırım AK et al. · Scientific reports · 2026 · Preclinical

    PMID 42204242 — View on PubMed