Research Comparison
Ipamorelin vs Sermorelin
A side-by-side research comparison of Ipamorelin and Sermorelin drawn from DRPSHP' peptide database records.
Ipamorelin
What made Ipamorelin interesting in its original animal pharmacology was what it did not do. Older growth hormone-releasing peptides raised ACTH and cortisol alongside growth hormone; in those studies this one did not, and that selectivity is the reason it is still discussed. It is a synthetic pentapeptide, Aib-His-D-2-Nal-D-Phe-Lys-NH2, derived from the earlier compounds in the class and a residue shorter than both GHRP-2 and GHRP-6, acting as an agonist at the ghrelin receptor GHS-R1a. Because that receptor also sits in the gut, rodent models of gastrointestinal motility have used it as well. A small number of human clinical studies exist; the bulk of what is known is animal work, and human data remain limited.
Sermorelin
Sermorelin is a synthetic peptide of 29 amino acids that reproduces the front end of human growth hormone-releasing hormone (GHRH). The natural hormone has 44 residues, and the 1-29 segment, with an amidated C-terminus as here, is reported to keep the receptor activity of the whole. Like the hormone itself it is cut rapidly by plasma enzymes including dipeptidyl peptidase-4, a vulnerability that later analogues such as tesamorelin were modified to avoid. Research has centred on growth hormone release from the anterior pituitary, including human physiology studies, many decades old, together with animal and cell work. Recent literature on sermorelin itself is sparse beside that for newer GHRH analogues.
Reading a comparison
A comparison places two records side by side; it does not merge them. Each description above is drawn from that compound's own record, and the two were not necessarily characterised by the same methods, at the same time, or to the same level of detail. Before comparing any attribute, it is worth establishing that both records describe the substance you think they describe — names are not identifiers, and two entries sharing a name can differ in salt form, stereochemistry or the convention used to state a mass. Where a figure carries no method beside it, the comparison is between two reported numbers rather than between two measurements.